Journal article
A. Davidyan, K. Baar, S. Bodine
The FASEB Journal, 2019
The FASEB Journal, 2019
Semantic Scholar
DOI
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APA
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Davidyan, A., Baar, K., & Bodine, S. (2019). Testosterone Is Not Required for The Maintenance of Muscle Mass in Fully Matured and Elderly Male Mice. The FASEB Journal.
Chicago/Turabian
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Davidyan, A., K. Baar, and S. Bodine. “Testosterone Is Not Required for The Maintenance of Muscle Mass in Fully Matured and Elderly Male Mice.” The FASEB Journal (2019).
MLA
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Davidyan, A., et al. “Testosterone Is Not Required for The Maintenance of Muscle Mass in Fully Matured and Elderly Male Mice.” The FASEB Journal, 2019.
BibTeX Click to copy
@article{a2019a,
title = {Testosterone Is Not Required for The Maintenance of Muscle Mass in Fully Matured and Elderly Male Mice},
year = {2019},
journal = {The FASEB Journal},
author = {Davidyan, A. and Baar, K. and Bodine, S.}
}
Abstract
Testosterone (T), the main androgenic hormone, is assumed to play an important role in the maintenance of skeletal muscle mass and function through its effects on satellite cell proliferation and differentiation, as well as its activation of pathways downstream of the IGF‐1 receptor and AKT. T depletion through chemical castration as a treatment for prostate cancer and the use of T to treat sarcopenia are both common practices in older humans, yet the majority of animal studies aimed at elucidating T's role in the maintenance of skeletal muscle mass are performed in young rodents under the age of 3 months. In addition, the role of T's activity in skeletal muscle health remains equivocal, with some studies showing circulating T to have great importance, while others suggest a limited or non‐significant role. Hence, the aim of this project was to characterize the phenotypic outcome of T depletion on skeletal muscle across lifespan and identify the contributing molecular pathways.
